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SRF can also bind to a distinct promoter element found in many genes that encode actin cytoskeleton associated proteins [19].
Since IFNs λ bind to a distinct membrane receptor, they would not be detected in the bioassay used here.
Transcription factors bind to a distinct point of the chromosome in a cooperative manner and recruit RNA polymerase II and other proteins forming a large transcription initiation complex, and finally make the RNA copy of the gene in question.
NASs bind to a distinct site on the GABAA receptor and influence the frequency and duration of the chloride channel openings, thus modulating GABAergic transmission and GABA mediated behaviors (Paul and Purdy 1992; Lambert et al. 1995; Majewska 1992; Concas et al. 1999).
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Ligand binding may also by heterotypic, such that the ectodomain on each MESA chain binds to a distinct epitope on a given ligand.
Both molecules bound to a distinct conformational state of MDM2 with nM-μM affinities.
Moreover, interaction of cadherins with p120-catenin that binds to a distinct site is necessary for the stabilization of E-cadherin at the cell membrane [19].
A sample of cells were labelled with a FITC anti-CD14 antibody that binds to a distinct (non-competing) epitope from the antibody used for cell isolation (Immunotools, Friesoythe, Germany) and analysed by flow cytometry.
It binds to a distinct region of the NMDAR.
These results demonstrate that Fab1p and Vac7p bind to the N-terminal half of Vac14p, whereas Fig4p binds to a distinct site in the C-terminal half.
Using HA4 as a competitor in phage-disply library sorting, we identified an Abl SH2 monobody, designated 7c12, that bound to a distinct site.
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