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Poliovirus receptor (PVR) and Coxsackie virus-adenovirus receptor (CAR) bind to a depression around the five-fold axes, called "canyon", on poliovirus and coxsackie B viruses (CVBs), respectively.
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Benzodiazepines bind to a specific receptor site of the GABA receptor, and thus the degree of modulation is limited, which explains the 'ceiling effect' of their central nervous system (CNS) depression.
The Ig-like domains of these receptors bind to the depression around the five-fold axis, which is called a canyon.
Gabapentin binds to a channel.
Yes, an emu bound to a lake, bound forever to walk the perimeter of the lake.
It weakened to a depression on September 19.
Jeanne weakened to a depression on November 14.
If one out of five people are bound to experience depression at some point in their lives, then this is no longer my story to tell, but ours.
And with porn addiction, as is the case with all compulsive behaviors (drinking, drug use, gambling, shopping, etc)., negative life consequences are bound to occur -- depression, anxiety, isolation, loneliness, shame and more.
In this orientation, the nucleosome appears to bind over a central depression formed between the Swr1 ATPase and the Rvb1/Rvb2 ring.
Reagan changed that to "a new depression — the Carter depression".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com