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To be broadly neutralizing, an Ab should bind to a conserved epitope with a relatively high affinity.
Furthermore, recent experiments have shown that Hox proteins bind to a conserved regulatory region of Shh, thereby promoting Shh expression within developing mouse limb buds [26].
In contrast, RpaB was found to bind to a conserved promoter sequence of hliB and various PSI genes under low light conditions [32], [33].
ESMA analysis showed that SmTRα could bind to a conserved DNA core motif as a monomer or homodimer.
Pluripotency factors Oct4 and Sox2 can bind to a conserved promoter region of the miR-302 to initiate its expression [42].
The tri-tyrosyl motif has been shown to bind to a conserved N-acetyl d-glucosamine mimicking sequence present in cytokeratin 14 (33) and N-acetyl d-glucosamine residues on cytokeratin 5 (19).
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Peptide triazoles have been found to bind to a highly conserved site that overlaps the CD4 binding site on gp120.
The primers and probe were designed to bind to a highly conserved region on the nucleoprotein gene.
GATA type transcription factors are zinc finger containing proteins that bind to a highly conserved DNA sequence motif ('WGATAR'WGATAR
They bind to a highly conserved region in the HA stem region and share the fusion peptide as a part of their epitopes.
Rapamycin binds to a highly conserved cytoplasmic receptor FK506-binding protein-12 (FKBP12).
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