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Recently, calmodulin-related proteins have been identified that specifically bind to a certain myosin, e.g. a light chain binding to Toxoplasma gondii Myo14A [TgMLC-1, [ 16]], or the light chain binding to Accanthamoeba castellanii Myo1C [AcMICLC, [ 17]].
Ligand based virtual screening is relatively fast, however the method requires previously known ligands that bind to a certain target; this hinders its universality and large-scale application.
Computer prediction of peptide epitopes can be based on known motifs for peptide sequences that bind to a certain MHC molecule, on algorithms using experimental data as a training set, or on structure-based approaches.
A significant correlation was observed between the TEPITOPE-predicted promiscuity (ie the number of HLA-DR molecules predicted to bind to a certain peptide) and the number of HLA-DR molecules that could actually bind the peptide in biochemical assays [45].
We will discuss here the repression protein molecules may bind to a certain promoter region of their own DNA, and thus decrease or completely stop the transcription.
Genomic approaches have shown that some miRNA subpopulations preferentially bind to a certain argonaute protein (Ago1, Ago3, Ago4 - which might be redundant- and Ago2) in a context dependent manner with different implications in carcinogenesis.
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Spiker, a former chairman of the Iowa G.O.P., forwarded to BuzzFeed's Rosie Gray a link to a book by a member of the Rules Committee, Curly Haugland, which claims that elected delegates aren't bound to a certain candidate even on the first ballot.
The museum also says that lights are kept low in many galleries for conservation reasons, not solely out of respect for Mrs. Gardner's wishes, and that the museum is not legally bound to a certain light level by the terms of her will.
The simulation process is bound to a certain procedure in order to generate valid and realistic results (see Fig. 5).
Table S1 in Additional File 1 shows how often an inhibitor binds to a certain group of kinases (group in a phylogenetic meaning).
Your contribution to statutory insurance is legally bound to a certain percentage of gross salary (at the moment between 12% and 15%, depending on the company).
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