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TFs bind to a broad spectrum of binding sites with different affinity and change targets widely among species.
TLR2 is expressed on many cell types and has been reported to bind to a broad array of microbial components [67], most notably lipoproteins [68], but also peptidoglycan [35], [69], and recently a bacterial porin [70].
It is well known that LILRB1 and LILRB2 bind to a broad range of classical and non-classical HLAIs [13], [14], [15] and major histocompatibility complex (MHC) class I-like molecules, such as UL18 [16].
LIR-1 has now been shown to bind to a broad range of MHC I molecules.
These results suggest that the HBV core protein might bind to a broad spectrum of human gene promoters, especially those featuring high CpG density.
In contrast, corepressors bind to a broad region of TRs, including the hinge region that is located immediately adjacent to the DBD.
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The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs.
Haloperidol, a typical antipsychotic, is non-selective and binds to a broad range of receptors, exerting efficacy mainly through the antagonism of dopamine receptors.
Thus, p53 phosphorylated at S46 is bound to a broad spectrum of target genes of which the apoptosis genes constitute a specific subset.
Already before autovaccination, the study patients had serum antibodies that bound to a broad antigen spectrum of their infecting S. aureus strain.
It has been shown that, in the nucleus, β-catenin binds to a broad spectrum of transcription factors other than TCF and LEF and modulates a plethora of downstream targets possibly contributing to cancer stemness and malignancy (Table 1).
More suggestions(18)
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bind to a cis-acting
bind to a Ca
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bind to a random
bind to a transcriptional
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com