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Selectivity is the property of a drug to preferentially bind to a biological structure.
Oligonucleotide in the unnatural L-configuration, also known as Spiegelmer, which has been designed to bind to a biological target of interest.
During the last 10 years, the fragment-based drug discovery (FBDD) paradigm, where a lead compound is evolved from small molecular fragments that bind to a biological target, has to an increasing extent been implemented both within academia and the pharmaceutical industry [ 1– 3].
Similar(57)
Therefore, many workers in the field engage in surface bioconjugation of NPs, usually with the goals of making nanomaterials that (i) are biocompatible and (ii) would bind to a particular biological target in or on a living cell.
As their abundant surface amine groups have the ability to bind to a range of biological molecules, Au DENPs have the potential to be a useful MI probe for CT.
Some of the responses can be predicted for targeted drugs, which have been designed to bind to a specific protein that triggers the biological response.
Secondly, they anchor various molecules to the sides of the nanowire that bind to specific biological targets.
These structures can bind to various biological materials and enter cells via endocytosis.
For example, if a small molecule adopts an appropriate 3-D shape and possesses compatible functional groups properly oriented in 3-D space, it will likely bind to the biological moiety of interest.
The drug affinity describes the ability of the molecule to bind to its biological target (e.g. receptor, enzyme, transport system).
While numerous three-dimensional structures of the bromodomain family have been experimentally determined, only a few are of the complexes of BRD bound to a lysine-acetylated-peptide of a biological binding partner [6], [24] [28].
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