Sentence examples for bind the substrate in from inspiring English sources

The seventh conserved residue (Asp135) has no direct interactions with either substrates or products, but it is hydrogen-bonded to Arg227, which does bind the substrate in the catalytic site.

Similarly, levodione reductase also utilizes the electrostatic interaction between a positively charged surface of the substrate and a Glu residue to bind the substrate in the specific orientation (Sogabe et al. 2003).

However, R269 did not directly bind the substrate in any of the simulations.

Here, we only considered the protonation states which are required to bind the substrate, in particular, Lys184 was considered to be positively charged and Glu191 to be neutral.

For example, hydroxylation of Lys(Me/ iPr) was only observed with JMJD2E, suggesting that of the tested enzymes, only JMJD2E is able to bind the substrate in an orientation amenable to oxidation on the isopropyl CH3.

Upon phosphorylation of the substrate by endogenous Src kinase, the SH2 domain of the biosensor binds to the substrate in cis, and produces a change in the emission spectrum.

Cas8′ alone (5 nM) bound 55% of the substrate in distinct complexes (labelled B in Figure 3D, lane 3).

The ankyrin groove of ankyrin-repeat domains is a common binding site for protein protein interactions, suggesting that this region of ASB9 may bind the substrate and orient it in a suitable way to allow polyubiquitination.

SPOUT structures utilize conserved residues to bind the AdoMet substrate in a binding cleft formed by the knot.

Conversely, a biosensor domain (BS) must bind its complementary sequence on the substrate in order to unlock the catalytic core (turning on).

The biosensor must bind its complementary sequence on the substrate in order to unlock the SOFA module, thereby permitting the folding of the catalytic core into the on conformation.