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Upc2p and Ecm22p bind the same sequence and the binding is dependent on sterol concentration [ 21].
However, VvMYB5bR did activate the VvCHI promoter when co-expressed with the co-factors AtEGL3 (bHLH) and AtTTG1 (WDR) in grapevine cells, but was not able to bind the same sequence in yeast one-hybrid experiments.
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This suggests that expression of prep1.1 is either auto-regulated, or regulated by one of its partners or paralogs (Pbx or Meis) whose dimers can bind the same sequences.
Neither is it seen in embryos mutant for the repressor Yan (FlyBase: aop), which is known to bind the same sequences as Pnt (data not shown).
Binding to the same sequence that binds Sp1 and Sp3, c-Krox was suggested to act in concert with Sp1 and Sp3 to modulate UGDH gene expression [ 11].
In this case, we have demonstrated CUGBP2 binds to the same sequence, but inhibits COX-2 mRNA translation [28].
The C. elegans genome contains at least seven LIM homeodomain TFs, most of which have uncharacterized binding sites, so it is possible that several of these proteins bind to the same sequences.
Besides GR and AP-1 motifs, many additional 8-mers, such as the CRE TGACGTCAandand CTCF motif (AGGGGGCG) have a high INOS, which indicates that many TFs bind to the same sequences calculated to be well-bound by the nucleosome and produce an intrinsic competition between TF and nucleosomes for binding the same DNA.
We found that this new chimeric gene encodes a nuclear protein that binds DNA with the same sequence specificity as the parental Oct-4 protein or the fusion EWS-Oct-4 protein.
Nucleosome N-2 DNA was pulled down more efficiently in chromatin preparations from asf1Δ cells than wild type cells, suggesting that Pho4 and histones bound to the same sequences simultaneously [23].
Binding signals resulting from the same sequence were extracted from the microarray and the effects on coexisting (combinatorial) modifications in the H3 tail were assessed.
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