Sentence examples for bind the same receptor from inspiring English sources

Many known 5-HT7 ligands contain either a serotonin-like or an arylpiperazine structure that, in published SAR studies, are generally supposed to bind the same receptor pocket.

The cytokines encoded by these two genes bind the same receptor, which is upregulated by IFN-γ [43].

Epiregulin and AREG are ligands that are coregulated, bind the same receptor and have genes found on same chromosomes.

IL-17 and IL-17F are highly homologous and bind the same receptor, implying shared biological activities.

Within each subfamily, receptor and ligand pairing is not mutually exclusive; in other words, multiple ligands can bind the same receptor and vice versa (for review see [ 80]).

If the shared amphipathic α-helix was a minimal binding motif, then 4F should be able to compete with known and novel SR-A ligands alike, since both seem to bind the same receptor site.

In nearly all cases the ligands in the cluster also bind the same receptors and vice versa.

Interleukin-1RA is an IL-1R antagonist that binds the same receptor on the cell surface as IL-1, preventing IL-1 signalling.

While simple cytokines typically have a single active site that binds the same receptor or family of receptors in each indication, mAbs typically perform diverse functional activities, with multiple aspects of the same molecule interacting with diverse receptors [ 21,25,26].

Angiopoeitin-1 (Ang-1) promotes stabilization and maturation of new blood vessels, whereas angiopoietin-2 (Ang-2), which binds the same receptor (Tie-2), can either promote VEGF-induced angiogenesis or destabilize blood vessels, causing endothelial apoptosis and leakiness in a context-dependent fashion [ 2- 4].

Potential protein targets are selected by evaluation of molecular mechanics energy and, while applicable, further analysis of its binding competitiveness against other ligands that bind to the same receptor site in at least one PDB entry.