Sentence examples for bind the active site from inspiring English sources

Compound 5d, which had the highest antimalarial activity, could bind the active site of falcipain-2 via the interaction scheme shown in Fig. 8.

The proposal that activation is a consequence of the movement of the N-terminus of the regulatory domain away from the active site predicts that molecules that bind the active site should do so more readily with the activated enzyme.

Although these molecules have been implicated in a variety of cell processes including cell growth and arrest (Stetler-Stevenson, 2008), they are primarily associated with their ability to bind the active site of MMPs preventing their protease activity.

Docking results suggested that compound 5d could bind the active site of falcipain-2 (Fig. 8) with binding energy of 8.5 kcal/mol.

Interestingly, DGN can bind the active site of GALC but in order to fit the binding pocket, residue W524 must alter conformation (Fig. 7D).

By mimicking the structure of cellulose chain, these oligosaccharides bind the active site of CBHs (Kont et al. 2013).

These inhibitors belong mainly to the Kazal, Kunitz and α2-macroglobulin families and they use a lock-and-key mechanism with their reactive site loops to mechanistically bind the active sites of the target proteases [8].

They can therefore bind the active sites of similar proteins and thus generate possible side effects.

The amino-terminal domain of TIMP binds the active site of MMPs, inhibiting their proteolytic activity.

Two nonpeptidic non-zinc chelating inhibitors in the S1′ pocket were found that could be crystallised in the presence of an acetohydroxamate anion that bound the active site Zn2+ ion (Morales et al, 2004).

These inhibitors can bind to the active site without substrate bound (transition state analogs, competitive inhibitors) or with substrate already bound (uncompetitive inhibitors).