Sentence examples for bind the active pocket from inspiring English sources

If true, then it could be predicted that self-compatible S-pollen protein should bind the active pocket region, thus impeding the binding of the general inhibitor.

In the molecular modelling study, compound 9i was bound in to the active pocket of EGFR with four hydrogen bonds and two π cation interactions having minimum binding energy ΔGb = −54.4 kcal/mol.

In the molecular modeling study, compound 7k was bound in to the active pocket of EGFR with three hydrogen bond and one π cation interaction with minimum binding energy ΔGb = −54.6913 kcal/mol, as well as compound 7b was bound in to the active site of FabH with hydrogen bond and π sigma interactions with minimum binding energy ΔGb = −45.9125 kcal/mol.

Interestingly, DGN can bind the active site of GALC but in order to fit the binding pocket, residue W524 must alter conformation (Fig. 7D).

Molecular docking studies showed that compound 4 bound to the active site pocket of the enzyme while compounds 15, 16, and 20 did not.

In the optimized geometries, 7a and 7b, NO2 − is loosely bound in the active site pocket and make hydrogen bonds with the active site residues Asn52 and Gly549.

First, nitrate gets loosely bound in the active site pocket by weak interactions with the active site residues Asn52 and Gly549 resulting in the substrate complexes 5a (5b) (Fig. 5).

Such positioning of the HK residues suggests that they are unlikely to interact directly with the target mC or C bound inside the active site pocket.

Structural analysis reveals that the substrate peptides are loosely bound within PR active pocket to form a wide contact interface between them, and thus mutation of just single or few residues seems not to influence PR substrate binding considerably.

These molecules bind specifically in the active site pocket where both the position of the ring nitrogen and its positive charge determine increased stabilization of GALC.

This result suggests that the MBDC binds well in the active site pocket of tankyrase and interact with the amino acid residues.