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Several aptamer sequences were found to bind preferentially to the M11 M-type of S. pyogenes.
The fungicides bind preferentially to the NADPH form of the enzyme.
We infer through careful analysis of X-ray photoelectron spectra that the Pt nanoparticles bind preferentially to the pyridinic nitrogen of the 4AMP.
We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP.
We report the systematic rational design and synthesis of new monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP.
Knowing the inactive and active conformations of the liver enzyme and how each differs from its counterpart in muscle phosphorylase provides the basis for designing inhibitors that bind preferentially to the inactive conformation of the liver isozyme.
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In this bigenic model, Cre recombinase is fused to a modified estrogen nuclear receptor in which the estrogen-binding domain binds preferentially to the estrogen agonist tamoxifen rather than to endogenous estradiol.
Nutlin-3 is a small-molecule inhibitor that binds preferentially to the p53-binding pocket of MDM2, leading to stabilisation of p53 and activation of the p53 pathway.
Also competition with an excess of cold unmethylated Sp1a probe was more efficient than with a methylated probe, indicating that Sp1 binds preferentially to the unmethylated Sp1a binding site within the epcam promoter.
Shifts in the kinetic properties of threonine deaminase promoted by isoleucine and valine binding are to a first approximation consistent with analyses of effector binding isotherms in terms of a simple two-state model, and suggest that isoleucine regulates threonine deaminase by preferentially binding to the low activity T state, whereas valine binds preferentially to the high activity R state.
The latter also binds preferentially to the target and avoids non-specific binding.
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