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This mutation leads to aggrecan core proteins of different lengths, with an over-representation of core proteins able to bind only a low number of chondroitin sulfate chains among those with severe disc degeneration.
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Although Mss4 tightly binds a series of exocytic Rab GTPases, it exercises only a low catalytic activity.
It has only a low affinity for monomeric O-GlcNAc, but binds oligomeric O-GlcNAc derivatives with high avidity.
This conclusion is further supported by the observation that the short proline-rich motif-containing version of peptideA binds only with a very low affinity to NOXA1-SH3 (Kd>70 µM; an exact determination of this dissociation constant was not possible due to a low heat change and the low affinity of the interaction).
Moreover, most of the enzymes involved in these metabolic processes bind only to a specific substrate, and probably for this reason, their degrees are relatively low.
Hypoxyprobe™-1 (Chemicon Europe Ltd, UK), or pimonidazole hydrochloride, is a compound which binds only to cells with a low O2 tension (Peters et al, 2004).
Altogether, our results indicate that river sediment estrogenic activity is mediated by a) low-affinity estrogens that bind only ERs, b) most AhR ligands that activate ER-mediated expression through AhR, and c) a minority of AhR ligands that activate both ERs and AhR.
But the Jets are in a bind, only $1 million under the $62.172 million salary cap.
Scaffold proteins bind only one molecule at a time.
Human antigens in a human cell bind only to the antihuman antibodies and express high signal for a subset of human antibodies and low signal for all the mouse antibodies.
These constructs bind only the active, GTP-bound conformation of Cdc42 to produce a fluorescence signal.
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CEO of Professional Science Editing for Scientists @ prosciediting.com