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These results are consistent with kinetic data indicating that NNRTIs bind more slowly to Lys103Asn mutant than to wild-type HIV-1 RT.
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The dominant theory held that alum particles bind the antigen--the vaccine's main ingredient--on their surfaces, presenting them more slowly to the immune system and thus ensuring a more thorough response.
Change came more slowly to my apartment.
Quarterly top line grew, albeit more slowly, to $2.3 billion.
"IBM, Oracle and Microsoft are always going to respond more slowly to market.
Real change evolves more slowly to define an era.
Substrate protein binds more slowly than ATP and thus in vivo is likely to bind to the tilting and elevating apical domains.
Hence compound 1 binds more slowly and dissociates a little more slowly than oseltamivir, and inhibits 15-fold more weakly, but still in the low nanomolar range.
By contrast, in UNC-13S-rescued animals, the EGTA-resistant component of evoked responses was dramatically reduced, indicating that UNC-13S primed SVs bind calcium more slowly than in wild-type controls.
Candesartan, which binds more tightly to and dissociates more slowly from the AT1 receptor than other ARBs, had the weakest PPAR-γ modulatory activity [ 5, 6].
The full picture was bound to emerge more slowly – drip-fed, if you wish.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com