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Only two of these scaffoldins, ScaC and a ScaE-like protein, contain dockerins that are members of a group (1b), which would presumably bind large numbers of carbohydrate-active enzymes.
Most transcription factors recognise small degenerate motifs and if single occurrences of these motifs in accessible chromatin give sufficient occupancy to generate a ChIP signal, then even short blocks of accessible chromatin may be seen to bind large numbers of different DNA binding proteins.
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In fact, HS chains can bind large number of proteins and several bioactive molecules like growth factors, chemokines, cytokines and enzymes to the cell surface and ECM, thereby regulating their availability and function in the control of some physiological processes, such as cell-cell and cell-ECM interactions [ 7].
(243) 19 shows fluorescence polarization measurements of microtubules bound to large numbers of fluorescently labeled kinesin molecules.
We compared this promiscuous interaction pattern of SHP with two well-known non-NR co-repressors, NCOR1 and SMRT, and found that these proteins also bind a large number of NRs (24 and 23 NRs respectively).
The problem may be compounded in situations where the TF binds to large numbers of sites in the genome (our reviewer recites a possible 32700 regions in the rat genome for CREB).
To the Editor: This article presents interesting research, but in a way that is bound to frighten large numbers of senior citizens.
Terpyridine binds a large number of metal ions and are readily functionalized giving rise to a plethora of available ligands as components in metallo-polymers.
A characteristic of PKCε is that it binds a large number of interacting proteins, indicating the generality of its actions.
Since HSF binds a large number of introns of genes that do not appear to be transcriptionally induced during HS, we decided to examine a subset of HSF-bound introns more closely.
The stock market is bound to fall when large numbers of workers retire, making equities unsuitable for retirement accounts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com