Sentence examples for bind into from inspiring English sources

More importantly, we found that Gln9 and Lys250, locating in the brim of the binding site, were ineffective to direct peptides to bind into the binding cleft.

Although the ligand binding site can be at the VFTM dimeric interface [9], [36], usually ligands bind into the VFTM binding pocket and in Class-C GPCRs binding of the natural ligands induces closure of the VFT responsible for receptor activation [12].

Moreover, the lowest-energy conformers of the six hit fragments are not observed in the same binding site, as shown in Figure 4. Therefore, the docking experiments do not indicate if the six fragments detected as ligands in the NMR screening bind into the same binding site and if so, which binding site it is.

Our results showed that most selective compounds against caspsase-3 bind into the substrate binding cleft acting as competitive inhibitors whereas in caspase-7 they bind close to an allosteric site at the dimer interface but since they are weakly bound their presence would not be affecting enzyme dynamics or function.

While drug design, in general, is focused on the discovery of small compounds that can bind into natural ligand-binding pockets or active centers of proteins of therapeutic interest, 194 inhibition of PPI requires identification of small compounds capable of disrupting a large and highly complementary interaction surface between two proteins.

For example, some proteins use β-ribbon or loop elements for major groove binding, and a few proteins bind into the minor groove.

Interestingly, both the substitutions bound into the binding cleft (Fig. 6D, F).

Molecular docking studies suggested that 9e binds into the colchicine binding site of tubulin.

As demonstrated by crystal structure it binds into the ATP-binding pocket of the kinase [ 37].

As anticipated, ponatinib binds into the ATP binding pocket between the N and C lobes.

Ponatinib binds into the ATP binding cleft in an extended conformation.