Sentence examples for bind in the same from inspiring English sources

At around the same time, a series of isoxazolidine-containing molecules named iTADs were described that bind in the same binding site of KIX as transactivation domains of proteins such as MLL, c-Jun, and Tat.

Thus, prodrug 1 seems to bind in the same binding mode and orientation to the DNA double-strand as drug 3, but, owing to the greater flexibility of the alkylating 1-chloroethyl moiety in prodrug 1 in comparison to the cyclopropyl moiety in 3, alkylation of both strands was possible (Fig.  15).

The observation that double combinations of neuraminidase inhibitors were not synergistic is consistent with the fact that all three drugs are known to target the same enzyme, and all bind in the same substrate binding pocket in a similar manner [19].

Given that all NAIs bind in the same substrate binding pocket in NA, the use of these drugs in combination in the absence of enhanced activity raises the risk of selecting for a single mutation that could confer resistance to both neuraminidase inhibitors simultaneously.

It is obvious that the phosphorylation of binding sites to which effector binding is described in another layer has to be treated differently than the phosphorylation of regulatory sites or the phosphorylation of binding sites to which the effectors bind in the same layer.

In general, fingerprint scoring yielded especially good results when the ligands in known complex structures bind in the same regions of the binding site, exhibit similar interactions and show a high affinity.

The docking study was performed using the LigandFit option of receptor ligand interactions protocol section available in Discovery Studio 2.1 where lower RMSD values (0.6931 Å) between the co-crystallized ligand and re-docked ligand assured that the ligand was bound in the same binding pocket.

All three ligands bound in the same pocket of CRBN and demonstrated similar binding modes, and very tight interaction with KD values of 250 nM (thalidomide), 178 nM (lenalidomide) and 157 nM (pomalidomide) measured by FP assays.

It is worth noting that Ala294 is the common residue for each ligand binding, and the result reveals that all the small compounds were bound in the same region of RbAp48.

The co-crystal structure proves that compound 3 binds in the same orientation as PLP, and confirms the mode of inhibition to be competitive.

The Blm10 C terminus binds in the same manner as seen for 11S activators and inferred for 19S/PAN activators and indicates a unified model for gate opening.