Sentence examples for bind in the pore from inspiring English sources
1b, 5 Pharmacologically distinguishing 5-HT3A from 5-HT3AB receptors has historically required the use of compounds that bind in the pore, such as bilobalide, ginkgolide, and picrotoxinin.
The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often differ.
To further examine how the ginkgolides might bind in the pore, we generated a homology model of the RDL receptor channel.
This value is considerably lower than values reported for GLIC and other Cys-loop receptors where it is known to bind in the pore and suggests that PXN mediates its action in ELIC by binding elsewhere on the protein.
These data therefore support our hypothesis that PXN could bind in the pore with high affinity at a location that would be expected given its homology to Cys-loop receptor pores.
Many of the NCAs that bind in the pore inhibit the 5-HT3R blockinging the channel, but allosteric modulators can also influence channel gating by binding to sites such as the inter-subunit region at the extracellular ends of the TMD α-helices (Trattnig et al., 2012).
The majority of these are non-competitive antagonists (NCAs) that bind in the receptor pore, and their differences in potency reflect the differing pore-lining residues of the 5-HT3A and 5-HT3B subunits.
The resonance angle changes proportionally with both the surface coverage of the molecules bound in the pores and the refractive index change of the free solution in the pore.
Until recently, discriminating between homomeric 5-HT3A and heteromeric 5-HT3AB receptors was only possible with ligands that bind in the receptor pore.
A substrate delivery model is suggested in which p31 transiently interacts with the TRIP13 N-terminal domain before MAD2 directly binds in the central pore.
10) In the Discussion section the authors discuss TRIP13's mode of substrate recognition, which seems to include an initial interaction of the p31 adaptor with the TRIP13 N-terminal domain, before the MAD2 substrate binds in the central pore.
