Sentence examples for bind in the major from inspiring English sources

This TFO was designed to bind in the major groove of the promoter, covering the CT-box (putative Sp1 binding) motif.

The "canonical triplex" structures of these studies have consisted of long stretches of uninterrupted homopyrimidine or homopurine strands, typically 12 14 bases in length, that bind in the major groove of duplex DNA, forming Hoogsteen or reverse Hoogsteen hydrogen bonds with bases in the homopurine or purine-rich strand of the duplex.

These proteins bind in the major groove of the K-turn that runs around the outside of the structure.

TFOs bind in the major grove of dsDNA, at homopurine homopyrimidine sequences, through either Hoogsteen or reverse-Hoogsteen interactions.

This would allow zinc clusters to reach their cognate DNA sites and bind in the major groove in the same way as Gal4.

TFO bind in the major groove on homopurine sequences of Watson-Crick-based antiparallel duplex DNA and are divided into Hoogsteen and reverse Hoogsteen formations by orientation of the third strand [ 5, 6].

The observation of intermolecular nuclear Overhauser effect connectivities demonstrated that TMPyP binds in the major groove of d GCTTAAGC 2.

The acceptor, Cy5, attached to the opposite strand at positions n (n = 7, 12, 14, 16, 19, 24, 27), binds in the major groove in two distinct locations on the upper and lower part of the groove.

Results of our detailed footprinting experiments indicate that EIAV Rev binds in the major groove of the double-stranded RNA stem corresponding to the high affinity Rev binding site in the ERRE, as is the case for HIV-1 Rev binding to stem-loop IIB, its cognate RRE.

The C-terminal helix, or recognition helix, binds in the major groove and an unstructured N-terminal arm binds in the minor groove.

The binding of Rev to the RRE is nucleated at the stem IIB hairpin, where the α-helical arginine-rich motif (ARM) of Rev binds in the major groove of the RNA and makes an extensive set of sequence-specific and electrostatic contacts (Malim et al., 1990; Cook et al., 1991; Heaphy et al., 1991; Kjems et al., 1991; Battiste et al., 1996).