Sentence examples for bind in the largest from inspiring English sources

Finally, peptides tend to bind in the largest pockets available on the protein surface.

Molecular-docking, molecular dynamics (MD) simulation and fluorescence-binding studies were undertaken to understand the role of N-terminal 59-residues in the binding of substrate/inhibitors. Molecular docking studies revealed that the PKR-inhibitor binds in the large hydrophobic cavity of the kinase domain of MARK4 through several hydrophobic and hydrogen-bonded interactions.

Molecular modeling analysis showed that GRA to be bound in the large hydrophobic cavity of MMP9.

In agreement with Dessen et al. working hypothesis, in our computationally-generated model Phe263 (P1) of huCollp261 is bound in the large nonpolar pocket 1 which was occupied by Met in the CII(1168 1180)/DR4 complex; Glu266 (P4) is hydrogen bonded to Lys71β as does P4 Asp in CII(1168 1180); Pro269 (P7) fits in the shallow pocket 7 (Fig. 2).

This helix only seems to be ordered when something is bound in the large cavity that is lined with FAD-derived mutations between TM2, TM3 and TM5.

3) Changing the question from finding sets with a given property to finding the lower bound of the largest number in a set with a given property and number of elements of such a set.

BT is bound remain the largest contractor in the near term at least.”.

Structure activity relationships among the amide series (10) and the reversed amide series (13) are similar, but not identical, especially in the case of the compounds bearing a bulky hydrophobic substituent at the distal benzene ring, indicating that the hydrophobic tail part of the molecules in these two series binds at somewhat different positions in the large binding pocket of PPAR.

It means that the computed lower bound can be considered in the large instances.

The underlying interpretation is that the high affinity to bind in the seed region between a given miR and mRNA fragment should be balanced by sufficiently large affinity to bind in the non-seed regions (regions 1 and 2).

It is found in vertebrate blood, bound by the large molecules, haemoglobin and myoglobin, where it binds to molecular oxygen when this gas is at a high concentration and releases it when the concentration is low.