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Fatty acid molecules have also been suggested to bind in the central cavities of potassium channels, blocking ion flux through the channel.
Providing that NPN would bind in the central cavity, as in AmelOBP14, the distance between DEET and NPN would prevent quenching and, therefore, the "lack of binding" suggested by DEET titration might be interpreted with caution.
For DNA to bind in the central chamber of the clamp loader, it must enter through the clamp opening as well as the gap in the clamp loader spiral, which in the T4 clamp loader is flanked by the andAndomainsains of the A subunit.
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Two inhibitor molecules are bound in the central RNA binding cavity of RNase A exploiting interactions with residues from peripheral binding sites rather than from the active site of the enzyme.
WDR5-0102-bound WDR5 has a backbone RMSD (root mean square deviation) of 0.4 Å (1 Å=0.1 nm) relative to the structure of WDR5 in complex with MLL and RbBP5 peptides [ 37] and binds in the central cavity within the arginine-binding pocket.
The 2D analysis of PBAF:nucleosome complexes indicates that the nucleosome binds in the central cavity.
The UTP binds in the central region of the enzyme, making contact with a loop formed by residues from Asp221 to Leu226.
Here, NPN is bound in the central cavity of the protein.
The KcsA-bound component is reduced in intensity in the presence of the TBA ion, showing that Dauda binds in the central cavity of KcsA.
A substrate delivery model is suggested in which p31 transiently interacts with the TRIP13 N-terminal domain before MAD2 directly binds in the central pore.
A single TBA ion binds in the central cavity of KcsA, and the effects of fatty acids and tetraalkylammonium ions on channel function are competitive.
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