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Molecular docking results showed that most of these compounds bind in the binding site of BCRP at the interface between the membrane and outer environment.
Sulfated low molecular weight lignins (LMWLs) have been found to bind in the heparin binding sites of coagulation proteinases.
Therefore, the sulfur atom of activated ISO is also able to form a di-sulfide bond with Cys61 like TAC and bind in the flavonoid-binding pocket.
The former mimic the substrate and are supposed to bind in the substrate binding site (SUB), a narrow hydrophobic tunnel [19].
These small, synthetic, homogeneous molecules bind in the GAG-binding site of proteins resulting in modulation of function.
Many small molecules bind in the T4 binding pocket of TTR and prevent its aggregation and amyloidogenesis cascade by stabilizing the native tetramer [ 27– 29].
Remarkably, modeling and X-ray crystallography reveal non-secosteroidal hybrids bind in the VDR ligand binding domain in the opposite orientation of their secosteroidal counterparts.
Second, the binding pocket has similar residues allowing different orientations of abacavir to bind in the absence of peptide.
(A) Flavonoids bind in the cavity (gray colored surface representation) that traverses the fatty acid binding channel.
Crystal structures of BnSP-7 binding to three different cinnamic acid derivates were solved showing that the ligands bind in the membrane-dockage region (MDoS) of the protein.
If we get him in a bind in the mountains, he may panic".
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