This lower bound, in conjunction with the upper bound from the dual, can be used to limit the optimality gap in larger cases where an optimal solution is not available.
HOX gene products bind DNA in conjunction with DNA-binding cofactors, which increase their binding specificity (Mann et al., 2009).
These ligands bind RET in conjunction with glycosylphosphatidylinositol-anchored co-receptors of the GDNF receptor alpha family, and the ligand-co-receptor-RET complex formation results in transient RET dimerization and activation of the RET tyrosine kinase domain.
Six light chains bound CL in conjunction with IS4VH (Figs 2a and 3).
Some classes of chromodomain proteins can bind to H3K36me3 in conjunction with PHD finger domains [ 20], but in vitro, Chd1 binds to nucleosomes methylated and unmethylated at H3K36 with a similar affinity [ 21].
Questions remain regarding the conditions governing the AtoC binding to these sites in vivo, i.e. whether AtoC binds alone or in conjunction with some other factor(s).
Thus, S100A8/A9 may induce cell activation after its nonspecific interaction with monocytes, because S100A8/A9 binds endothelial cells in conjunction with heparin sulfate proteoglycans and novel carboxylated glycans [ 11, 12].
The two crystal structures of APY and APY-βAla8.am bound to EphA4, in conjunction with secondary phage display screens, highlighted peptide residues that are essential for EphA4 binding as well as residues that can be modified.
β-Adrenoceptor-stimulation can affect sodium currents by PKA-dependent and PKA-independent mechanisms: PKA phosphorylates cardiac sodium channels, and sodium channels can directly bind to β-adrenoceptors in conjunction with G-protein α-units.
Upon exposure to mitochondrial toxins, parkin binds α-synuclein (PARK1), and in conjunction with the ubiquitin-conjugating enzyme Ubc13, stimulates K63-linked ubiquitination.
Fibrates activate PPARα, which binds to a PPARα response element in conjunction with the retinoid X receptor.
