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4– 6 AIs are characterized into two types: steroidal aromatase inactivators, which bind irreversibly to the androstenedione binding site of aromatase, and nonsteroidal AIs, which bind in a reversible fashion to the heme component of aromatase.
The LUVs were shown to bind, in a reversible fashion, to charged diethylaminoethyl Sephadex columns.
This architecture is achieved through a metal chelating surface, to which histidine-tagged (His-tagged) membrane proteins are able to bind in a reversible manner.
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Thus, Zn2+ should be considered as "attenuator" of KLK activity, which binds in a reversible manner to the targets for fine tuning of their proteolytic action.
Many NRs are common drug targets [ 33]; the recent identification of the endogenous ligand of HNF4α that binds in a reversible fashion also makes HNF4α a potential drug target [ 34, 35].
A mechanism consistent with the cumulative data from the present study is shown in Figure 6(B), in which mAb5E3 binds in a reversible fashion to a cryptic epitope that is revealed in the transition state during activation to intermediate, increasing its stability and accordingly reducing the unimolecular activation energy barrier.
Platelets have high-affinity binding sites for PGI2 that can also bind Iloprost in a reversible, saturable manner.
Paclitaxel binds specifically in a reversible manner to the N-terminal 31 amino acids of the beta-tubulin subunit in the microtubules rather than to tubulin dimers [ 47, 48].
Sigma factors bind to core RNAP in a reversible way in order to induce transcription.
These results indicate that LA is an exchangeable ligand that binds native HNF4α in a reversible fashion.
Proflavine is an acridine-derived dye which binds to DNA in a reversible and non-covalent manner.
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