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This is interesting, given that the N-terminal Nlys residue in ADP3 was not critical for IgY binding, possibly suggesting that the screening hits bind in a different fashion to the antibodies than does ADP3.
In contrast, when the carboxylate moiety is in ortho, ligands like diclofenac or meclofenamic acid bind in a different orientation.
Further, when a regulatory motif is not palindromic (motifs in this study are not palindromic), the cognate protein is likely to bind in a different orientation (relative to the TSS) to, for example, a CACA motif on the coding strand, as compared to a CACA motif on the non-coding strand.
Finerty and Bass suggest, on the basis of the difference in affinity of the N-terminal and C-terminal zinc fingers of ZFa, that these regions of the protein may bind to different forms of dsRNA or alternatively may bind in a different manner.
Alternatively, l-serine may allosterically bind in a different location, causing the C-terminal Cys 458 to be released from the Fe S cluster and subsequently to bind to His 124 and Asn 126, which could serve as a latch to prevent it from interfering with subsequent substrate binding at the active site.
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Perhaps before it arrived at HLS in 1946, the book was bound in a different binding at some point in its history.
Synthetic pot binds to the same brain receptors as its natural cousin, but it binds in a different way, with unpredictable results.
This implies that AV-45 binds in a different location or manner than L2-b.
The bound threads would be sent off to the dyer, and then returned to the tier, who would bind them in a different place for their second trip to the dyer.
The strandβ6a in Spy0129 is a novel feature that effectively divides the loop region into two parts and could allow them to move independently when substrates bind, and in a different way from the S. aureus and B. anthracis SrtB enzymes.
The presence of this bridge, however, causes the distal pyrrolidine/sulfonamide group to bind in a drastically different conformation compared to doripenem bound to OXA-1.
More suggestions(17)
combined in a different
engaged in a different
ties in a different
bind in a random
bind in a proper
bind in a sialic
bind in a Watson-Crick
bind in a nonproductive
bind in a conserved
bind in a double-strand
bind in a deep
bind in a competitive
bind in a reversible
bind in a single
bind in a third
bind in a head-to-tail
bind in a nonspecific
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