Sentence examples for bind differentially to the from inspiring English sources

The EGF ligands bind differentially to the ErbBs and initiate homodimeric or heterodimeric receptor dimerization to cause tyrosine phosphorylation of intracellular receptor residues and downstream cell signaling through mitogen-activated protein (MAP) kinases, phosphatidylinositol 3-kinase (PI3K), and transcription factors including STAT-3 [ 60, 61].

We performed DNA pulldowns with nuclear extracts of a SILAC-labelled mouse myoblast cell line (C2C12) to discover the repressor that binds differentially to the G3072A SNP in pigs.

Independent lines of evidence further support the functional identity of the protein: MGR binds differentially to the q variant of a SNP and functions as a repressor; mild overexpression induces the severe growth phenotype in C2C12 myoblast cells and knockdown of MGR results in upregulation of Igf2.

4. Why do Arfrp1 and Arf1 bind differentially to allow this cooperativity with the Vangl2 Yxxphi?

We investigated the possibility that phytoestrogens may bind differentially to estrogen receptor proteins (ER[alpha] and ERss) and affect the interactions of the ligand-ER complexes with different estrogen response element (ERE) sequences.

In addition, with the recent determination of the X-ray structure of sterol enzymes and the finding that azole drugs used to treat diseases of ergosterol biosynthesizing organisms can bind differentially to human and trypanosome 14α-demethylase enzymes opens the door for a new era of rational drug design.

The VEGF family consists of five structurally related ligands that bind differentially to their receptors (VEGFR-1, -2 and -3).

Using a biochemical approach, we have identified two classes of proteins that bind differentially to PABPN1 containing either normal or expanded polyalanine tracts.

However, they bind differentially to other pathogens.

We reasoned that this might be caused by diffusible glycosylated proteins or peptides which would bind differentially to lectins.

This is consistent with published data suggesting that for a protein to bind differentially to pathogenic dsRNA or endogenous dsRNA it must be capable of recognizing either specific RNA sequences or structural elements.