Sentence examples for bind at this site from inspiring English sources
Since the C+ mutation in CHC prevents clathrin binding to the mitotic spindle in concert with phosphoTACC3 (Hood et al., 2013), this argues that the compound either does not bind at this site in cells or that its binding is too low affinity to outcompete the interaction of clathrin TACC3 with microtubules.
Site directed mutagenesis of two residues located at either side of the pocket caused distinct resistance to the compounds, demonstrating that they indeed bind at this site.
AP1 family protein, such as c-Fos, c-Jun, JunB, JunD, ATF, Fra-1, Fra-2, and so on, can bind at this site by forming homo- or heter-dimer (Fig. 1).
Fourth, mutational analysis identified a final site probably between blades 6 and 7, although the sequence requirement for peptide ligands to bind at this site is still unknown (Willox and Royle, 2012).
As shown in Figure 3B, the locations of these hot spots are in good agreement with the positions of the three rings and the carboxylic acid group in several selective partial agonists, such as 5-chloro-1- 4-chlorobenzyl -3- phenylthio -1h-indole-2-carboxylic acid (also called nTZDpa), that bind at this site and activate PPARγ using an H12-independent mechanism (Bruning et al. 2007).
To bind Ca2 at this site, R347, W348, D370, D374, R373, and K378 undergo a dramatic series of conformational changes, with several residues rotating ∼180°, to effect calcium binding at Ca2.
The question of whether DRV might bind at this atypical site in wild-type enzyme can be addressed by structural comparison.
Interestingly, electron density was not observed at the Ca1 site in apoPAD4, suggesting that PAD2 binds calcium at this site with a higher affinity.
Here, OCC (or OCCUPIED) indicates that something, no matter what, is bound at this binding site, where FREE specifies the opposite.
The results suggest that NH3 molecules interact with both EDOT and SS and favor to bind at the sites of O and H atoms.
