Therefore, our results clearly show that such regions are involved in cholesterol binding and are also in agreement with the electron density data published by Lee et al.41 for the G5G8 transporter in which some features in the electron density map suggest that cholesterol is bound at this location.
Fig. 5D demonstrates the distribution of simulated RNA fragments by assuming protein binds at the location that has the highest correlation coefficient (marked with blue ellipse).
To determine over-represented TFBS motifs, Clover starts for every location in a DNA sequence, by calculating a score reflecting the likelihood that a certain TF binds at that location.
Therefore, the simplest way to produce such physical interactions is to bind at a location near the TSS, and our findings are consistent with this "Occam's razor".
In the central nervous system, glutamate is produced by glia and Schwann cells [ 3] or released at the synaptic gap by excitatory neurons; at this location, it binds to the various subtypes of glutamate receptors [ 4].
A unique property of VACV B18 is its ability to bind to the cell surface and prevent IFN signaling at this location (17, 18).
In particular, it was revealed that GFRA2 is positively regulated by miR-557, miR-765 and miR-17-3p that probably bind at different locations of the 5' UTR of this mRNA.
Furthermore, the ERK2 kinase binds stably to Tpr's tail and was proposed to have a role in cargo modification at this location (Vomastek et al, 2008).
It is obvious from various other works that ions bind at particular locations, but specificity has not been demonstrated clearly in this paper.
Specifically, the CLN2 promoter is constitutively available for SBF binding, whereas HO has a complex two-step promoter in which chromatin changes in one region allow SBF to bind at a downstream location.
