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This suggests that inhibitors could be designed to bind at this interface such as to prevent nucleotide-induced domain closure.
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Many biochemical studies support the view that the juxtaposed G- and T-segments bind at the interface of the B'/A' DNA binding and cleavage core and the ATPase domains [1].
Benzodiazepines bind at the interface of the α and γ subunits on the GABAA receptor.
FK506 is known to bind at the interface of FKBP12 and calcineurin [27].
Rapa is known to bind at the interface between FKBP12 and TOR, resulting in TOR inhibition [26].
We show that both Mal and TRAM are strongly predicted to bind at the interface of a TLR4 TIR homodimer, a result consistent with multiple other studies using mutagenesis of receptor and adaptor TIRs and blocking peptides.
Both ligands were shown to bind at the interface of two subunits.
Auxin itself can bind at the interface of Aux/IAA proteins and TIR1-family F-box proteins, components of specific SCF E3 ubiquitin ligases, directly promoting their interaction.
This study showed that the receptor binds at the interface of the subunits with three receptor molecules binding to one trimer, with two main sites of interaction on the ligand.
In this model, the peptide binds at the interface of the inner and outer domains, preventing folding of the bridging sheet and formation of the coreceptor binding site.
In chain A, the FAD is noncovalently bound at the interface of a Rossman-type domain and the substrate-binding domain.
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