Sentence examples for bind at the vinca from inspiring English sources

Tubulysins bind at the vinca domain of β-tubulin, thus disrupting microtubule assembly.

Similar to vinca alkaloids, maytansine and its analogs emtansine (DM1) which are microtubule-targeted drugs binding to tubulin at the vinca binding site can depolymerize microtubules and arrest cells in mitosis, resulting in a powerful anti-mitotic activity [7 10].

However, vinorelbine, which is also a microtubule-destabilising agent but binds to the Vinca alkaloid binding site, has its efficacy reduced by the overexpression of class III β-tubulin in vitro in breast carcinoma cells (as shown in this study) and in small lung cancer cells (Gan et al, 2007) and in vivo (Seve et al, 2005).

Compounds such as LY355703 (synthetic derivative of marine cryptophycins) induce mitotic arrest by binding at the microtubule vinca-binding domain.

They block cell division and prevent the correct formation of the mitotic spindle, by inhibiting tubulin polymerization, probably at the binding site of the Vinca alkaloids [ 19].

Here's his stockinged legs, bound at the ankles.

: Printed and bound at the "Republican" office, 1867.

It's bound at the top with a spiral wire.

Vinblastine causes microtubule depolymerization and targets both tubulin monomers and microtubules by binding to β-tubulin at a region adjacent to the GTP binding site known as the vinca domain.

Vinorelbine, from the vinca alkaloids binds with high affinity to the plus end of the microtubule and with low affinity to the sides of the microtubule and leads to depolymerization [ 46, 47].

Unlike the Vinca alkaloids, paclitaxel binds preferentially to polymerised tubulin and shifts the dynamic balance between tubulin dimers and microtubules towards microtubule assembly.