Sentence examples for bind at the folate from inspiring English sources

Most inhibitors are folate-analogs that bind at the folate binding site and are not species specific.

Figure 1 illustrates the process of receptor-mediated endocytosis (RME), by which folate bound to the folate receptor is internalized by a cancer cell.

The first mechanism, the fluorouracil metabolite fluorodeoxyuridine monophosphate contests with uracil to bind with thymidylate synthetase and the folate cofactor [5], these consequences in declined thymidine production and hence declined DNA synthesis and repair, and eventually declined cell proliferation.

Membrane-bound FRs mediate cellular uptake of folates via a non-classical endocytotic mechanism whereby folate ligands bind FRs at the cell membrane, followed by invagination and the formation of cytoplasmic vesicles (endosomes), (Fig. 2).

Similarly, D504 appears to bind to the polar edge of the folate and is also required for activity.

Once bound to the FR, folate conjugates are transported into the cell via receptor-mediated endocytosis.

In the absence of RFC1, the primary route of folate uptake into cells may be the GPI-anchored folate receptor, or internalization of folate bound to the soluble form of the folate receptor via endocytosis by megalin [ 28].

Multiple turnover experiments reveal that the folate remains bound to photolyase even after 10 turnovers of the enzyme.

Green Human lung carcinoma cell line lacking folic acid receptors Fig. 12 Column 1: represents the ability of the folate receptors to bind to the folic acid coated QDs, thereby labeling the cells.

We examined the potential nonlinear dose-response relationship between folate intake levels and breast cancer risk by modelling folate intake levels using restricted cubic splines with three knots at 10%, 50%and90%0% percentiles of the folate intake distribution.

The folate helps the nanoparticles bind to receptors on cancer cells.