Sentence examples for bind at the catalytic from inspiring English sources
Structure-based inhibitor design has led to the discovery of a number of potent inhibitors of glycogen phosphorylase b (GPb), N-acyl derivatives of β-d-glucopyranosylamine, that bind at the catalytic site of the enzyme.
However, the small fragment 44 binds at a distal site, while the more elaborated fragments 48 and 60 bind at the catalytic site, consistent with the docking predictions.
Xie et al. [ 1] suggested that in the set of catalytic-core TyrA proteins, inhibitors bind at the catalytic site and exhibit classical competitive inhibition with respect to the particular cyclohexadienyl substrates that can be accepted by a given organism.
In particular, compound K1 displayed the best AChE inhibition (404-fold higher than PDM), which suggested that phthalimide group of K1 strongly bound at the residues lining the gorge while phenyl N,N-dimethylcarbamate bound at the catalytic site.
Therefore, we favor the second hypothesis described in Figure 12 in which Fe3+-HO2R contwons two hemes - one bound at the catalytic site and the other at the HRM.
For instance, Piazzi et al. report AChE inhibitor purposely designed to bind at both the catalytic and the peripheral sites of the human enzyme [ 19].
The structures demonstrated that the inhibitors bind preferentially at the catalytic site and promote the less active T state conformation of the enzyme by making several favorable contacts with residues of the 280s loop.
Both L-NMMA and ADMA inhibit NOS-mediated NO production by competing with L-arginine to bind at the NOS catalytic site [ 83].
The Sod2 (mitochondrial SOD) binds manganese at the catalytic core and is located within the mitochondria [ 15].
The ferrous state (Fe2+) of 5-LO is not able to bind any substrate/product/inhibitor at the catalytic or regulatory site but it is able to bind Ca2+ at the catalytic site (see Figure 2(b)).
11 Alogliptin is a pyrimidine in structure and reversibly binds at the active catalytic site on the DPP-4 enzyme.
