Sentence examples for bind at the active from inspiring English sources

Additionally, the most potent inhibitors were shown not to be competitive, indicating they do not bind at the active site.

This result implies that CC-EO and trans-cinnamaldehyde affected the affinity of the enzyme for L-DOPA but did not bind at the active site (Webb 1963).

The physiological substrate l-serine is still able to bind at the active site of the inhibited enzyme, although catalysis does not occur.

The three-dimensional structure of this enzyme at 1.9 Å resolution with the inhibitor, diethyl 4-methylbenzylphosphonate (EBP), revealed that the inhibitor did not bind at the active site, but bound exclusively into a well-defined surface pocket 12 A away from the active site.

Through these interactions, the inhibitors bind at the active site so that the protease can be restricted to the closed configuration.

Furthermore, according to the 3D models, Cys289 has a favorable sulfur-aromatic interaction [18] with Tyr336 and is accessible for covalent bonding to small molecules that bind at the active site (Figure 2).

The ferrous ion bound at the active sites is essential for the activity of hydroxylases.

ITC shows that PatE2 C51A binds almost as tightly as PatE2, but as the internal cysteine is processed extremely slowly, we conclude this binding is non-productive; the Ala at position 51 is bound at the active site.

While in XDH the two residues seem to determine which substrates are efficiently bound at the active site, in mAOX1 more factors determine the binding and conversion of substrates.

Specifically, the effect of KCl concentration on HDAC8 activity was investigated by Fierke and co-workers using HDAC8 with two different divalent metal ions (Co2+ and Zn2+) bound at the active site.[ 5] These experiments revealed a bell-shaped activity profile, with an activating effect at lower concentrations of K+ and an inactivating effect as the concentration was increased.

In general, SODs have a strict metal binding specificity for enzymatic activities with the exception of a class of enzymes which show enzymatic activity regardless of whether Fe or Mn is bound at the active site; these are known as cambialistic forms [ 2- 5].