Sentence examples for bind at multiple sites from inspiring English sources

Transcription factors like Sp1 can bind at multiple sites and protect the CpG island promoter from being silenced [ 35- 37].

For the TREX components Gbp2 and Tho2 and export receptor Mex67 hits mapped across mRNA bodies, consistent with their proposed ability to bind at multiple sites.

First, SU HW) frequently binds at multiple sites within LADs, while the other four insulator proteins mainly bind outside LADs (Fig. 2a, Fig. S2a).

CTCF binds at multiple sites throughout the genome [ 2- 4], indicating a widespread role in generating chromatin domains.

Immunofluorescence staining using anti-GFP antibody and Hoechst showed that ectopically expressed tBRD-1-eGFP binds at multiple sites along polytene chromosomes (Fig. 7A).

We show that like SH2-Bbeta, APS binds JAK2 at multiple sites and that binding to phosphotyrosine 813 is essential for APS to increase active JAK2 and to be phosphorylated by JAK2.

Maturation of LRP to the trans-Golgi network is partially dependent upon the presence of LRP-receptor-associated protein (RAP), which binds to LRP at multiple sites to block the receptor's ability to interact with its ligands [11].

We have previously shown that the peptidyl-prolyl cis-trans isomerase Pin1 binds phosphorylated PML at multiple sites that include S403 and S518 and promotes its degradation in triple-negative MDA-MB-231 breast cancer cells [ 126].

Each of these proteins had large binding regions which offered ample room for the ligand to bind in multiple conformations and at multiple sites within the binding region of the protein.

The Fixed-Randomized primers bind with full sequence complementarity at multiple sites where the fixed sequence (such as the splice signals) occurs within the genome, and multiplex amplify many regions bounded by the fixed sequences (e.g., exons).

We believe that the peptide binds to α-crystallin subunits, at multiple sites, as in the case of βA3/A1- 102-117) peptide binding to αB-crystallin [35], to bring about conformational change sufficient to increase the overall hydrophobicity of the complex above that of native protein.