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One intriguing question is how two sets of compounds, the classical aminocoumarins and the simocyclinones, which are evolutionarily related, target the same enzyme (gyrase) but bind at different subunits.
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(A ) Nef binds to different subunits of AP-2 (top) and AP-1 (bottom), but docks onto the membrane in both cases.
It demonstrates that PsaH binds to four different subunits that may be important attribute for the known stability of plant PSI.
Only four of the eight different subunits bind ATP at physiological concentrations.
The peripheral V1 domain complex responsible for ATP hydrolysis contains at least eight different subunits (subunits A-H).
PSI consists of 12 different subunits and binds more than 100 cofactors, making it a model protein to study different aspects of membrane protein biogenesis.
We next delineated the modular architecture of SWI/SNF by deleting different subunits once at a time from the complex and comparing the structure of intact SWI/SNF with those missing particular subunits.
Furthermore, since Mcm2-7 likely act sequentially, different subunits will have different nucleotide bound states at a given time.
The drug A769662 and the natural product salicylate mimic the ability of AMP to inhibit Thr dephosphorylation and cause allosteric activation, but bind at a different site involving the β subunit [ 16– 16].
Moreover, the Sr/Fe ratio, though generally marked by higher values, is indicated by fluctuating distributions, not only at the boundary between but also within different subunits (particularly subunit II, LEF 44, 45; Fig. 3).
As β1 integrin subunit binds with different α subunits, we wanted to determine if suppression of uPAR expression had any effect on the cell surface expression of α integrin subunits in HCT116 cell lines.
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