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Furthermore, as seen with the PSA promoter region, WT1 and SP1 may bind at adjacent sites or potentially at overlapping sites since WT1 also binds at EGR1 sites [ 7- 9].
WT1 and SP1 may bind at adjacent sites within the PSA promoter or at overlapping sites, since the SP1 site overlaps the EGR1 site, to which WT1 may also bind [ 7- 9].
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For example, Pax5 binds specifically to the CD79α promoter and recruits Ets proteins to bind at an adjacent site, forming functional ternary complexes that allow the expression of CD79α in the B cell lineage [50].
Similarly, when two factors bind to adjacent sites on DNA (co-binding), they may not actually interact with each other, i.e. no cooperative interactions.
DND1 has been shown to bind to the 3'-UTR of mRNAs to displace miRNAs that bind to adjacent sites on the same mRNA [8].
Expression of FGF4, therefore, requires the combined activity of these two transcription factors that bind to adjacent sites on the FGF4 enhancer DNA region [ 59].
We have identified AP-1 as one of the collaborating transcription factors that preferably bind to the adjacent sites surrounding STAT1 binding regions.
In addition to chromodomain binding to the histone tail, AT-Hook/ATHL can bind to the adjacent site in the minor groove of DNA, sandwiching the DNA between PC and histone surface (see Additional file 8).
DNase I footprinting analysis of DevRC with the tgs1-Rv3131 interegion revealedevealed that it binds to the primary site, but fails to cooperatively bind to the adjacent site, unlike full-length DevR which protected both the sites (Fig. 2).
5′-Inosinate binds to an adjacent site close to the binding site for glutamate.
Correlation of sediment color profiles at two adjacent Sites U1426 and MD01-2407.
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