Sentence examples for bind at a distinct from inspiring English sources

Previous work has shown that oxysterols modulate Smoothened in an allosteric manner; that is, in contrast to several other known modulators of this protein, oxysterols bind at a distinct site (Nachtergaele et al., 2012).

On the basis of the significant structural differences between indolotryptolines and known V-ATPase inhibitors, it would not be surprising that they bind at a distinct site and therefore have selected for unique resistance-conferring mutations.

Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the active site termed the NNRTI pocket.

This finding indicates that compounds from series 2 bind at a site distinct from both substrate-binding sites.

Unlike nucleoside reverse-transcriptase inhibitors, which bind at the enzyme's active site, nevirapine binds allosterically at a distinct site away from the active site termed the non-nucleoside reverse transcriptase inhibitor pocket.

Based on the findings that GF quenches tryptophan fluorescence of the colchicine-tubulin complex [ 12] and that colchicine can depolymerize GF-induced polymers of tubulin in the presence of MAPs at 4°C [ 13], it was suggested that GF binds at a site distinct than the colchicine binding site in tubulin [ 12].

Our data show that this probe labels the NCA site and demonstrate that the NCA insecticide fipronil binds at a site distinct from that of other NCAs, such as picrotoxinin and 4′-ethynyl-4-n-propylbicycloorthobenzoate.

PSA inhibition was achieved using two unrelated small molecular weight compounds: bestatin, a natural, slow binding, competitive inhibitor of many aminopeptidases (35), and PAQ-22, a synthetic, non-competitive inhibitor that does not act as a substrate-mimic and binds to PSA at a distinct site (36– 36).

SRF can also bind to a distinct promoter element found in many genes that encode actin cytoskeleton associated proteins [19].

Various activating ligands were identified, which may bind with a distinct affinity to VEGFR family members.

The CD8 co-receptor also binds to pMHCI, but at a distinct site, and allows the potential for tripartite TCR/pMHCI/CD8 interactions, which can increase T cell antigen sensitivity.