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Since that discovery, CIB1 has been shown to bind and regulate a variety of signaling proteins [8], [18], [19], [20].
Phosphoinositides bind and regulate a plethora of proteins at the interface of the cytosol and cellular membranes.
Table 1 shows that a significant proportion of genes are TF genes (90 of 353), suggesting that the core TFs in turn bind and regulate a large number of other TF genes in the ES cells [ 2].
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We report the computational redesign of the protein-binding interface of calmodulin (CaM), a small, ubiquitous Ca2+-binding protein that is known to bind to and regulate a variety of functionally and structurally diverse proteins.
Consistent with a global role in maintaining quiescence, E2F4 has been shown to bind to and regulate a set of proliferation and cell cycle related targets in a number of ex vivo human cell lines, including glioblastoma [8], [13], fibroblast [14], and osteoblasts [15].
It has been shown that several syntaxin-binding proteins, such as tomosyn, possess a SNARE-like coiled-coil domain that would allow them to bind to and regulate a SNARE complexes [ 10].
"It can bind and regulate all sorts of things.
In addition, K+ binds and regulates a number of intracellular enzymes including RNA polymerase (as potassium glutamate) [45].
Hox transcription factors bind nuclear DNA pervasively and regulate a plethora of target genes, deploying various molecular mechanisms that depend on the developmental and cellular context.
These results provide further mechanistic insights into Dali's mode of action and indicate that Dali and POU3F3 form a complex that binds to and regulates a subset of genes in trans in N2A cells.
We divided these genes into four groups based on whether they are more likely to bind and regulate RNA in a gene-specific or nonspecific manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com