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The KIPs bind and inhibit a broader spectrum of cdks than do the INK4s.
Gwl phosphorylates Ensa and Arpp-19, two related factors that, upon phosphorylation, specifically bind and inhibit a protein phosphatase complex named PP2A/B55δ.
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p21 (Wand/CIp27 and p27 bind to, and inhibit, a range of Cyclin/CDK complexes, resulting in inhibition of cell cycle progression (Coqueret, 2003).
In most invertebrates and vertebrates, these compounds bind to and inhibit a ubiquitous P type Na+/K+ ATPase.
Conclusions: Our results show how BFRs or their metabolites can bind to and inhibit a key hormone-metabolizing enzyme, potentially causing endocrine disruption.
Other cellular enzyme inhibitors are proteins that specifically bind to and inhibit an enzyme target.
Drug discovery is a tricky and costly process 42, and nowadays usually involves the search for a molecule that can bind tightly to (and inhibit) a chosen molecular target.
doi: 10.7554/eLife.06671 Image The virus Transcriptional Activation Protein (TrAP; orange) binds to and inhibits a plant enzyme Viruses are parasites that depend on their host to be able to replicate.
Some in vitro replication assays have shown that the Rb amino-terminus can bind and inhibit MCM7, a component of the replicative helicase that is important for replication initiation and elongation [19], [25].
This suggests that Nec-1s, in contrast to Nec-1 and Nec-1i, will not bind and inhibit IDO, a prediction that was experimentally tested (next section).
Upon ABA binding, these receptors increase their ability to bind and inhibit the clade A type 2C protein phosphatases (PP2Cs), including ABI1, ABI2 and HAB1.
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