Sentence examples for bind and cleave a from inspiring English sources

Deoxyribozymes (DNAzymes) are catalytic nucleic acids that bind and cleave a target RNA in a highly sequence-specific manner.

Cas9 is easily targeted to bind and cleave a DNA sequence via a complementary RNA; this straightforward programmability has gained Cas9 rapid acceptance in the field of genetic engineering.

This study also showed that directing Cas9 to bind and cleave a specific DNA sequence did not require an RNA complex.

DNAzymes or catalytic oligonucleotides are new classes of gene targeting molecules that bind and cleave a specific mRNA, resulting in decreased protein expression.

ZFN (zinc finger nucleases) and TALENs (transcription activator-like effector nucleases) make use of engineered chimeric nucleases that are designed to bind and cleave a specific DNA sequence (Gaj et al. 2013).

Nevertheless, since ZFNs can be designed to bind and cleave a wide range of endogenous DNA sequences, it will be a powerful tool to generate gene mutation and endogenous chromosomal fragment deletion and might find other broad applications in basic research and biotechnology soon in the future [ 131].

Zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeat-Cas9 system (CRISPR-Cas9) represent a powerful array of tools that can bind to and cleave a specified DNA sequence.

The Cas9 protein can be programmed to bind and cleave any desired section of DNA – but now Church's new approach activates the genes Cas9 binds to rather than cleaving them, triggering them to activate transcription to express or repress desired genetic traits.

DNAzymes are single-stranded catalytic DNA molecules that bind and cleave specific sequences in a target mRNA molecule.

Alternatively, the P. tricornutum Dicer-like enzyme, which shows a partial sequence conservation with plant and animal Dicer homologues and possesses only a dsRBD domain followed by 2 RNAs III domains [ 30] might bind and cleave the opposite strands of a dsRNA in an atypical way to generate the miRNA-like molecules identified in this study.

By comparing these substrates to type I proteins not regulated by γ-secretase, we determined that besides a short ectodomain, γ-secretase requires permissive transmembrane and cytoplasmic domains to bind and cleave its substrates.