Sentence examples for bind and block from inspiring English sources

This is especially true for calcineurin (CN), in which the blockbuster immunosuppressant drugs FK506 and cyclosporin A were recently demonstrated to bind and block one of the key CN substrate interaction sites, the LxVP site.

The interaction of these IFNα/βBPs with GAGs at the cell surface does not interfere with their ability to bind IFN-I, since mutant proteins that failed to attach to the cell surface retained the ability to bind and block IFN-I with high affinity21.

The bee venom phospholipase A2 (PLA2) inhibitory activity of petrosaspongiolide M (PM), a marine metabolite displaying a potent anti-inflammatory activity and able to covalently bind and block group II and III secretory PLA2 enzymes, has been investigated by mass spectrometry and molecular modeling.

Co-founded by Barres back in 2011, after mouse data suggested blocking C1q could be beneficial for multiple neurodegenerative and autoimmune diseases, Annexon has developed several antibodies that can bind and block the action of the complement protein.

We demonstrated that HIV infection could be inhibited using a strategy aimed at HIV-specific molecular interactions with Caulobacter surface protein display, and that sufficient protein folding and conformation could be mimicked to bind and block entry.

Alternatively, extracellular components have been shown to bind and block the entry of the another aminoglycoside antibiotic, tobramycin (29).

To address this question, we first screened chemical library to identify a compound that can bind and blocks surface localization of gp96.

However, in the presence of the inhibin co-receptor betaglycan, inhibin forms a high affinity interaction with the activin type II receptor, inhibiting the ability of activin to bind and blocking activin-induced signalling [ 46].

MAMs' crucial role of conducting apoptosis signals was demonstrated by previous study: after ER- mitochondria contact points were bound and blocked by keratin- binding protein, cells were resistance to apoptosis after oxidative stress exposure [ 71].

When dissolved in milk, the long coiled glucomannan chains bind up and block the movement of water molecules, and thicken the milk.

We define here the structural requirements for small peptides to competitively bind to and block the s4A position to prevent this intermolecular linkage and polymerisation.