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The design of the siderophore binding pocket gives siderocalins the ability to bind a wide variety of siderophores and protect the host against several pathogens.
However, phenylboronic acids are non-selective and bind a wide variety of cis-diols.
Sigma receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents.
They were initially proposed to be related to opioid receptors [2] but were later found to be a distinct pharmacological entity distinguished by an unusual promiscuous ability to bind a wide variety of drugs [3].
This chapter illustrates the use of a new, rapid, and widely applicable zinc finger-engineering strategy that produces three-finger domains that bind a wide variety of DNA sequences.
Regarding the latter, NHERF can bind a wide variety of signaling ligands (ie. EGFR, PDGFR, β-catenin, PTEN, and adrenergic and purinergic receptors, to name but a few) with functional consequences [18], [41].
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Albumin binds a wide variety of hydrophobic ligands.
Pin1 binds a wide variety of signaling proteins to control their activity and/or protein−protein interactions (Liou et al. 2011).
As albumin, it binds a wide variety of hydrophobic ligands including fatty acids, bilirubin, retinoids, flavonoids, chemical drugs, and metal ions (Terentiev and Moldogazieva 2013).
The high AUC result for WDI is expected since it contains marketed and in-development small molecule drugs that bind to a wide variety of protein targets.
They bind to a wide variety of small molecules and fatty acids and carry of them to different parts of the body.
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