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N-terminal sequences are thought to bind a number of partners (Beland & Roucou, 2012), with binding of Cu II) and Zn II) ions by the OR being an area of active interest (reviewed in Millhauser, 2007).
Our hypothesis is that if the TF is active in a tissue, it will bind a number of target sequences, thus the putative TF binding sites will be overrepresented in the DNase HS regions (see Methods for details).
SpA is a multifunctional protein that has been shown to bind a number of ligands including IgG and Tumour Necrosis Factor Receptor1 (TNFR-1).
Following a proteomic approach, we have found that B. anthracis spores bind a number of human serum proteins that are involved in humoral and innate immunity.
These coactivators bind a number of sequence-specific transcriptional activators and have been suggested to be central integrators of transcriptional signals from various signals transduction pathways [13].
They bind a number of haematopoietic transcription factors (GATA1, E2A LMO2, SCL, LDB1), CTCF or components of the transcriptional machinery and are associated with relevant histone modifications, accessible chromatin and low nucleosomal density.
Similar(35)
Whereas no mammalian partner was thus far associated with the PDZ-binding motif of NleH1, a previous report demonstrated that EspI binds a number of PDZ-containing proteins, including NHERF1 and NHERF2 (Lee et al., 2008).
Chp binds a number of effector kinases including PAKs [26], [27] and is reported as an early expressed neural crest marker in Xenopus [28].
They identify a protein kinase, ULK3 that binds a number of components of the ESCRT III com-lex.
HA binds a number of ECM proteins, including fibronectin, as well as cell surface receptors, including CD44.
Indeed, the multidomain Pins binds a number of other proteins, including the microtubule anchoring protein NuMA [ 20].
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