The Fab fragment of K42-41L, that binds a loop on rhodopsin, was crystallized with a peptide mimic of the epitope that fits snuggly in the peptide-binding cleft of the antibody.
Clegg, who runs the 200m and 100m, maintains contact with her guide Mikail Huggins, using a loop of physiotherapy tubing, bound in the middle with electrical tape.
Interactions between upstream and downstream bound PTB could result in a looping of the RNA, thereby shielding specific sequences from functionally interacting with both splicing enhancing factors and the spliceosome [22].
In the Rho mechanism, six nucleotides of ssRNA occupy the channel, with each nucleotide potentially being bound by a loop derived from each subunit of the hexamer.
The flaps being mobile structures [ 36] that open out to let the substrate pass, one can imagine that a molecule drug-designed to bind the external loop of the protease flaps could block their mobility, therefore keeping the protease from processing its substrate.
Using the human beta 2 adrenergic receptor, ascorbate was found to bind to an outside loop of the receptor, near the agonist binding site.
Since they bind the second loop of the three-finger snake toxin with high affinity and selectivity, nAChRs could be exploited to facilitate BBB crossing and intracranial transport of drug delivery systems.
This indicates that Nob1 primarily binds over the loop of H40, with only transient interactions at cleavage site D. The PIN domain is characterized by three Asp residues that coordinate a divalent metal ion.
The crystal structure of a truncated variant of the aptamer in complex with GRK2 and Gβγ (PDB ID: 3UZT) revealed that an adenine nucleotide in a hairpin loop of the RNA aptamer binds in the active site in a manner that mimics the substrate ATP.
On the basis of chemical shift perturbation, all eight compounds were found to bind to the GYGF loop of NHERF1 PDZ1 in a manner similar to that of F0911 3941.
