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Each MHC protein can bind a large set of different peptides.
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We also find that NEUROD2 binds to a large set of genes with functions in layer-specific differentiation and in axonal pathfinding of cortical projection neurons.
The three Myc proteins are basic helix-loop-helix leucine zipper transcription factors that heterodimerize with a binding partner, Max, to bind DNA and either activate or repress the transcription of a large set of target genes [ 1- 3].
Furthermore, we have found by ChIP-on-chip a large set of genes commonly bound by Ndt80 and by Sum1.
We also assess the quality of our solutions by computing a lower bound of the optimal solution, and by representing a large set of locally optimum solutions.
Secreted type I IFN binds to cell-surface type I IFN receptors to amplify and spread the antiviral response, inducing transcription of a large set of antiviral, IFN-stimulated genes (ISGs).
REST, a transcription repressor that binds the RE1 element to repress neuronal genes in non-neurons [ 9, 14- 16], similarly showed preferential occupancy in a large set of regions depleted for other TFs and for initiating Pol II.
A large set exulted in his fellowship.
These compounds may be part of a larger set of small molecules that bind to Aβ fibrils and possibly shift the equilibrium from toxic high MW oligomers and protofibrils.
Further, it is known to bind a large number of proteins with high specificity implying that its intrinsic mechanism of binding is finely tuned to respond to its diverse set of targets.
By contrast, thiocyanate is able to bind the largest set of amide protons including some well-protected amide protons located on electrostatically negative patches.
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