Sentence examples for bind a large proportion from inspiring English sources

Transport receptors of the importin family bind a large proportion of nucleoporins and have been proposed to regulate the post-mitotic formation of NPCs by blocking the relevant interactions between NPC components (Harel et al. 2003; Walther et al. 2003b).

Genome-wide studies of CREB in hepatocytes have not examined CREB DNA binding dynamics, but have shown that CREB binds a large proportion of gene promoters that are not induced by cAMP [ 6, 14].

Together, our results show that the MEE2-interacting factor (MIF) also binds to related motifs found in a large proportion of var upstream regions.

In agreement with previous literature [ 34], a large proportion of CTCF bound regions and H3K4me3 marks are shared among cell types, whereas DNase-seq data sets are in greater variation.

Another possibility is that there is a large proportion of nonspecifically bound radiolabeled BP in the injected solution but this is unlikely after the extensive purification and characterization experiments.

The clinical significance of this vulnerability might be that a large proportion of toxins that bind to plasma proteins cross the choroid plexus [ 31] and diffuse into the CSF, from where they can reach the individual brain structures.

Indeed, interrogation of Oct4 ChIP-seq data demonstrated that a large proportion of the Otx2 binding regions are also occupied by Oct4 in mESCs and commonly bound regions contain the Oct4 consensus binding motif.

There are many proteins associated with the U2 snRNP, and a large proportion of them are transiently bound.

Further analysis of FUS and EWS ChIP-seq peaks revealed that a large proportion of target genes were bound by both FUS and EWS (Fig.  3 and Additional file 6).

Data from Aventis Pharmaceutical company suggest that a large proportion of S3705 is plasma bound and our results confirm that a higher concentration of S3705 is needed to inhibit Na+-dependent Cl−/HCO3− exchange in the presence of serum.

Genes bound by GATA1, GATA2, or PU.1 were generally expressed at higher levels than genes not bound, implying that these TFs contribute positively to regulation of a large proportion of MP, E, and N cell transcriptomes.