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This ability of PDI to bind a large number of different molecules prompted us to search whether potential encocrine disruptor compounds (EDCs) could exert an influence on its reductase activity.
Further, it is known to bind a large number of proteins with high specificity implying that its intrinsic mechanism of binding is finely tuned to respond to its diverse set of targets.
These ERs also have capacity to bind a large number of synthetic ligands [13], [15] with affinities similar to that of the natural ligand or for some ligands a thousand fold less than that for 17β-estradiol.
The ability of NKX2-5Y191C aNKX2-5∆HD∆HD to bind a large number of targets was unexpected.
HBc has the ability to bind a large number of human gene promoters, and can disrupt normal host gene expression.
This implicates 50 200 negatively charged disaccharide units in each GAG chain due to the attached sulfate groups [ 26] which can bind a large number of positively charged molecules.
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Terpyridine binds a large number of metal ions and are readily functionalized giving rise to a plethora of available ligands as components in metallo-polymers.
A characteristic of PKCε is that it binds a large number of interacting proteins, indicating the generality of its actions.
Since HSF binds a large number of introns of genes that do not appear to be transcriptionally induced during HS, we decided to examine a subset of HSF-bound introns more closely.
This increased TG-rich single-stranded DNA would then bind a larger number of Cdc13 molecules, thus increasing the probability of telomerase recruitment at the short TG tract telomeres.
In addition to the above described targets, CagA has also been reported to bind to a large number of proteins in an EPIYA phosphorylation-dependent manner.
More suggestions(15)
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Justyna Jupowicz-Kozak
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