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They constitute a multigenic family of receptors which collectively bind a diverse array of – exogeneous as well as endogeneous – ligands.
The activating receptors bind a diverse array of ligands, some of which are stress-induced or virally encoded [2].
However, biochemical analyses indicate that CD1d molecules can bind a diverse array of ligands that include substantial variation in radyl group structures [10] [13].
GPCRs bind a diverse array of ligands including proteins, lipids, neurotransmitters, calcium, odorants, and other small molecules [ 1].
Adeno-associated viruses (AAVs) have been isolated from a wide variety of species and are reported to bind a diverse array of cell surface carbohydrates including heparan sulfate proteoglycans, N- and O-linked sialyated glycans, and glycoshingolipids (reviewed in [5]).
Alternatively, the Ciona VDR/PXR may function more like vertebrate PXRs, and assist in protection from toxic levels of endogenous and/or exogenous compounds, in which case it might bind a diverse array of ligands.
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GRP94, the endoplasmic reticulum Hsp90 paralog, binds a diverse array of peptides, a subset of which are suitable for assembly onto nascent MHC class I molecules.
In contrast to TRBV, TRBD and TRBJ genes which encode products that bind to a diverse array of peptide-MHC ligands, TRBC gene products interact with components of the CD3 complex which are non-polymorphic.
In mammalian cells, members of the G-protein-coupled receptor family, which couple primarily to heterotrimeric G-proteins and β-arrestins, initiate a wide range of signaling events involved in several cellular processes when they bind to a diverse array of ligands, such as hormones and peptides (Musnier et al., 2010; Shukla et al., 2011).
Carefully mapped short synthetic peptides that contain the dominant T cell epitopes of major allergens and bind to a diverse array of HLA class II alleles, can be delivered intradermally into non-inflamed skin to induce sustained clinical and immunological tolerance.
The inter-conversion between these two actin forms is tightly regulated by a diverse array of proteins that bind actin directly or indirectly.
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