Key binary switches in the mouse blastocyst are regulated by pairs of transcription factors [36], [37] that govern cell fate decisions.
Overall, Integrator does not appear to act as a binary switch in JUNB regulation, and instead, it appears to exert fine regulation over JUNB, consistent with a role in regulating transcriptional flux/the dynamic range of activation.
6) Evidence that BRM/SYD can turn a gradient into a binary switch (presented in the Discussion) is lacking, or at least the evidence the authors are drawing upon needs to be pointed out more clearly.
For example, what's the evidence that the conditional BRM allele is really a null? 6) Evidence that BRM/SYD can turn a gradient into a binary switch (presented in the Discussion) is lacking, or at least the evidence the authors are drawing upon needs to be pointed out more clearly.
Roy, K., Bandyopadhyay, S. & Atulasimha, J. Binary switching in a 'symmetric' potential landscape.
These signaling molecules are binary switches in crucial cellular processes including growth, differentiation and survival [ 75].
The two-state nature of the process is indeed apparent in several complementary observations that do not depend on the measured timescales: (1) the single exponential distribution of lifetimes; (2) the distribution of molecular extensions; (3) the binary switching patterns observed in the experimental traces; (4) and the results from the HMM model.
This binary switch system of the Ras protein is localized to conformational changes in two distinct regions comprising switch I and switch II [ 10].
The PT operates a novel binary switching mechanism in which the relative proportion of individual EYA3-expressing cells reflects the circannual phase.
However, within the simplicity of the coarse-grained model, the molecular simulations strongly support the main result derived from our experiments; namely that, starting from a downhill free-energy landscape, the pulling force induces a free-energy barrier that results in binary switching between the native and a partially extended unfolded state in patterns that indicate a two-state description.
