Sentence examples for binary regulation from inspiring English sources

We obtained a binary regulation matrix of transcription factors and H2H genes after completing the above analysis (see Additional file 4).

Because modification of histone tails in enhancer regions influences DNA accessibility, we wanted to determine if the binary regulation (activation or repression) of enhancers corresponds to the binding of specific TFs during EMT.

While the RNA-guided nuclease Cas9 has been repurposed as a programmable transcription regulator, its application has typically been limited to binary on/off regulation and thus misses informative and potentially optimal intermediate levels of gene expression.

The major advantage of our reformulation is its easy integration of (binary) transcriptional regulation.

This has been proposed to explain the graded versus binary effects of regulation observed in some miRNA interactions [11].

Let E u and E d denote the up and down regulation binary matrices, respectively.

Efforts have been made to place gene expression in context of global behavior using descriptors such as breadth of gene expression [ 12] and distributions characteristics that represent ubiquitous, binary, or graded regulation [ 19- 23].

Overall, Integrator does not appear to act as a binary switch in JUNB regulation, and instead, it appears to exert fine regulation over JUNB, consistent with a role in regulating transcriptional flux/the dynamic range of activation.

The identified circuit design happens to be consistent with a purely binary logic viewpoint of regulation.

Cyclic oscillations of hes genes in stem cells have been correlated with the maintenance of pluripotency and regulation of binary cell fate decisions, thereby generating cell type diversity (reviewed in [ 80– 80]).

There is also extensive experimental documentation of sigmoidal or binary responses in gene regulation [ 5, 11- 16] as well as theoretical justifications based on classical principles from physical chemistry [ 17- 20].